The Gravity Recovery and Climate Experiment Follow-On (GRACE-FO) mission is a partnership between NASA and the German Research Centre for Geosciences (GeoForschungsZentrum, GFZ) in Potsdam, Germany. NASA's Jet Propulsion Laboratory (JPL) in Pasadena, California, manages the mission for NASA's Science Mission Directorate (SMD) at NASA Headquarters in Washington, under the direction of the Earth Systematic Missions Program Office at NASA's Goddard Space Flight Center in Greenbelt, Maryland.

At JPL, Phil Morton is the project manager. Frank Webb is the project scientist, and Felix Landerer is the deputy project scientist. Mike Watkins is the Science lead and also the director of JPL.

At NASA Headquarters, Thomas Zurbuchen is the associate administrator for SMD, and Dennis Andrucyk is deputy associate administrator. Sandra Connelly is the deputy associate administrator for programs. Michael Freilich is the director of the Earth Science Division within SMD. Eric Lanson is associate director for flight programs, Jack Kaye is associate director for research, and Lawrence Friedl is associate director for applications within the Earth Science Division. David Jarrett is the GRACE-FO program executive and Lucia Tsaoussi is the GRACE-FO program scientist.

At GFZ, Frank Flechtner is the GRACE-FO project manager. Franz-Heinrich Massmann is the mission operation system manager. Christoph Dahle is the science data system manager.

GFZ has subcontracted mission operations to the Zentrum für Luft- und Raumfahrt (DLR), which operates the German Space Operations Center in Oberpfaffenhofen, Germany. At DLR, Sebastian Löw is the GRACE-FO mission operation system manager.